Behaviora1 neurology has primarily focused on brain behavior relations as revealed by disorders of the cerebral cortex and subcortical gray matter disorders of cerebral white matter have received less attention this article considers the contribution of cerebral white matter to normal behavioral function and the effects of white matter disorders on behavior. More than 100 neurologic diseases injuries and intoxications are known to prominently or exclusively involve the white matter of the brain12 without exception these disorders have the potential to disrupt aspects of cognitive and emotional function and to lead to important syndromes related to white matter dysfunction. Behavioral neurology is founded on lesions of cortical gray matter but recently the contributions of cerebral white matter to cognitive and emotional dysfunction have also attracted attention the behavioral neurology of white matter surveys this broad and fascinating field from a clinical perspective. White matter and behavioral neurology christopher m filley md director behavioral neurology section professor of neurology and psychiatry university of colorado denver school of medicine. Despite these seminal behavioral neurology reports the role of white matter in clinical syndromes remained relatively ignored in the early part of the 20th century until it was reenergized by the influential and eminent work on cerebral disconnection syndromes by norman geschwind geschwind 1965
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